Ivermectin 12 mg + Albendazole 400 mg is a combination antiparasitic used for treating intestinal helminths and related worm infestations, with improved efficacy for Trichuris and hookworm compared with albendazole alone in several programs and studies. Ivermectin binds invertebrate glutamate-gated chloride channels, causing paralysis of parasites, while albendazole inhibits microtubule polymerization and glucose uptake, leading to parasite death. Co-administration is deployed in deworming and filariasis control and is generally well tolerated in community use, with programmatic endorsements and observational evidence supporting broader impact against soil-transmitted helminths and selected ectoparasites. Always follow medical guidance.