Amlodipine is a dihydropyridine calcium channel blocker used for hypertension and angina, producing vasodilation by inhibiting L‑type calcium influx in vascular smooth muscle to lower peripheral resistance and myocardial oxygen demand. It improves exercise tolerance and relieves chronic stable and vasospastic angina by reducing afterload and preventing coronary spasm, with long duration that supports once‑daily therapy. Mechanistically, its membrane‑selective, slow on–off binding yields sustained arterial relaxation with minimal effects on cardiac conduction at therapeutic use, aiding blood pressure control without reflex tachycardia in chronic dosing. Clinical resources endorse its role across coronary and hypertensive care.