Sildenafil citrate 100 mg + Dapoxetine 100 mg refers to an on‑demand dual therapy conceptually targeting erectile dysfunction and premature ejaculation, but authoritative evidence supports dapoxetine only at on‑demand doses of 30–60 mg, with no established efficacy or routine use for a 100 mg dose in PE management. Clinical data show dapoxetine coadministration with sildenafil has no clinically meaningful pharmacokinetic interaction, yet studied and marketed fixed‑dose combinations typically pair sildenafil 50–100 mg with dapoxetine 30–60 mg rather than 100 mg. Any higher‑dose pairing should be clinician‑directed after assessing indications, comorbidities, and timing needs.