Sildenafil citrate 50 mg + Dapoxetine 30 mg is a fixed on‑demand combination addressing coexisting erectile dysfunction and premature ejaculation: sildenafil enhances penile blood flow via PDE5‑mediated cGMP potentiation, while dapoxetine delays ejaculation through short‑acting serotonin reuptake inhibition in central pathways. Clinical studies of the 30/50 mg pairing report improvements in intravaginal ejaculatory latency and patient‑reported outcomes, with supportive evidence that dapoxetine and sildenafil lack clinically meaningful pharmacokinetic interactions when coadministered. Such combinations are commercially available in multiple markets as single tablets to simplify coordinated timing before sexual activity.