Ciprofloxacin hydrochloride 500 is an oral fluoroquinolone antibiotic tablet strength commonly used for susceptible bacterial infections, including urinary tract, lower respiratory tract, gastrointestinal, skin/soft tissue, bone/joint, certain sexually transmitted infections, typhoid fever, and post‑exposure prophylaxis for inhalational anthrax and plague per approved labeling. Its use should reflect local resistance patterns and guideline selection, as fluoroquinolone resistance (e.g., in gonorrhea) limits empiric utility in some settings.