Dapoxetine is a short‑acting selective serotonin reuptake inhibitor used on demand for premature ejaculation, delaying the ejaculatory reflex by increasing synaptic serotonin within central neural pathways that regulate ejaculation, particularly via 5‑HT1A/1B/2C receptor–mediated modulation of spinal and supraspinal circuits. Taken one to three hours before sexual activity, it is rapidly absorbed, reaches peak levels in about one to two hours, and has an initial half‑life near one to two hours with terminal elimination around 19–22 hours, supporting situational rather than daily use under clinical assessment of PE criteria and patient distress.