Estradiol Gel 0.06% is a topical estrogen therapy used to relieve moderate to severe symptoms of menopause, such as hot flashes and vaginal dryness, by directly replacing estrogen that the body produces less of during menopause. This gel is commonly applied to the skin, dries quickly, and is clear and odorless once dry. Its effects typically begin within several weeks after starting treatment, providing targeted hormone replacement for women and may also be utilized for gender affirmation therapy in transgender and gender-diverse adults. Regular medical monitoring is advised to ensure the treatment continues to suit individual needs and that effectiveness is maintained.