Avanafil 200 mg + Dapoxetine 60 mg is an on-demand dual therapy pairing a fast-acting PDE5 inhibitor for erectile function with a short-acting SSRI for premature ejaculation, designed to enhance erections and delay climax in one tablet. Avanafil increases cavernosal cGMP by inhibiting PDE5, with rapid onset around 15–30 minutes and efficacy observed as early as 15 minutes, extending in some users beyond 6 hours. Dapoxetine inhibits serotonin reuptake in central ejaculatory pathways and typically reaches peak effect within 1–2 hours. Combined formulations at 200/60 mg exist in practice.