Tadalafil 40 mg + Dapoxetine 60 mg denotes an on‑demand pairing for erectile dysfunction and premature ejaculation, but evidence for combination regimens primarily uses lower doses such as tadalafil 5–20 mg with dapoxetine 30 mg, showing improved intravaginal ejaculatory latency and satisfaction versus either agent alone. Pharmacokinetic work indicates dapoxetine 60 mg has no clinically meaningful interaction with tadalafil 20 mg, supporting coadministration when clinically indicated, though direct data at 40 mg tadalafil are limited. High single doses of tadalafil may raise tolerability concerns, so dose selection is typically individualized and aligned with established reference ranges and trialed combinations.