Sumatriptan combined with naproxen is a medication specifically formulated for the acute treatment of migraine attacks, with or without aura, offering enhanced relief over either drug alone. Sumatriptan, a selective 5-HT1 receptor agonist, works by narrowing dilated blood vessels in the brain and inhibiting the release of inflammatory neuropeptides from trigeminal neurons, thereby alleviating headache pain and associated symptoms like nausea, photophobia, and phonophobia. Naproxen, a non-steroidal anti-inflammatory drug (NSAID) from the propionic acid derivative family, complements this by reversibly inhibiting cyclooxygenase enzymes, reducing prostaglandin-mediated inflammation and central sensitization in the brainstem. It also effectively addresses non-traditional migraine symptoms such as neck discomfort and sinus pressure, with consistent efficacy shown in menstrual migraines.