Minoxidil 5% combined with finasteride 0.1% topical solution is used to treat androgenetic alopecia (male pattern hair loss) by addressing hair thinning through dual mechanisms. Minoxidil acts as a vasodilator, increasing blood flow to hair follicles and promoting hair growth, while finasteride locally inhibits the 5-alpha reductase enzyme, reducing dihydrotestosterone (DHT) levels that cause follicle shrinkage. This combination improves hair density, thickness, and helps maintain existing hair. Clinical studies show that topical finasteride combined with minoxidil offers similar efficacy to oral finasteride but with fewer systemic side effects, making it a favorable option for long-term treatment.