Metformin PR 1000mg is a prolonged-release formulation of metformin hydrochloride, an oral antihyperglycemic medication primarily used to manage type 2 diabetes mellitus in adults. It works by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity to lower blood sugar levels effectively over time. This extended-release version allows once-daily dosing, typically with the evening meal, and is often prescribed as monotherapy or combined with other antidiabetic agents like sulfonylureas or insulin for better glycemic control. Clinical studies show it reduces cardiovascular risks, such as myocardial infarction, compared to diet alone. Available as tablets, it undergoes minimal accumulation with repeated use and achieves peak plasma levels around 5 hours post-dose.