Sildenafil citrate + Tadalafil refers to combining two PDE5 inhibitors—one typically used on demand and the other often taken daily—to address erectile dysfunction when monotherapy response is suboptimal, aiming to pair a fast‑acting agent with a long‑acting baseline effect under specialist guidance. Evidence from a randomized study suggests daily tadalafil 5 mg with on‑demand sildenafil 50 mg improved erectile function metrics versus tadalafil alone without higher adverse‑event rates in selected patients, though broader data remain limited. Expert commentary encourages cautious, case‑by‑case use given additive vasodilatory effects and the paucity of large trials specifically on dual PDE5 regimens.