Avanafil 100 mg + Dapoxetine 60 mg combines a fast-acting PDE5 inhibitor for erectile function with a short-acting SSRI for premature ejaculation to enhance erections and delay climax on demand in a single tablet. Avanafil increases penile blood flow during sexual stimulation by inhibiting PDE5 and sustaining cGMP, with rapid onset around 15–30 minutes and activity for several hours. Dapoxetine inhibits serotonin reuptake in central ejaculatory pathways, typically active within 1–2 hours of intake. Related PDE5–dapoxetine combinations show additive improvements in latency and satisfaction versus monotherapy.