Sildenafil citrate 100 mg + Dapoxetine 60 mg is an on‑demand combination intended for men with both erectile dysfunction and premature ejaculation: sildenafil boosts penile blood flow via PDE5‑mediated cGMP enhancement, while dapoxetine delays ejaculation through short‑acting serotonin reuptake inhibition in central pathways. Pharmacokinetic data in healthy men show coadministration of dapoxetine 60 mg with sildenafil 100 mg does not produce clinically important interactions, supporting coordinated use when clinically indicated under supervision. Fixed‑dose 100/60 mg tablets are marketed in some regions for convenience, aligning timing before intercourse to address both conditions together.