Vardenafil 20 mg + Dapoxetine 60 mg combines a PDE5 inhibitor for erectile dysfunction with a short-acting SSRI for premature ejaculation, aiming to improve erections and prolong intravaginal ejaculatory latency in a single on-demand tablet. Vardenafil enhances penile blood flow during sexual stimulation by inhibiting PDE5 and sustaining cGMP-mediated smooth muscle relaxation in the corpus cavernosum. Dapoxetine inhibits serotonin reuptake, increasing serotonergic activity in ejaculatory control pathways, which can delay ejaculation within 1–2 hours of dosing. Clinical evidence with related PDE5–SSRI combinations suggests additive benefits for latency and satisfaction versus monotherapy.