Clobetasol 0.05% is a super‑potent topical corticosteroid for short‑course control of inflammatory dermatoses such as plaque psoriasis, eczema flares, lichen planus, and severe localized dermatitis, rapidly reducing redness, swelling, and itch by suppressing cutaneous immune mediators and vasodilation for marked symptom relief. Apply a thin film to affected skin in brief bursts, avoid occlusion unless directed, and reserve for thick plaques or non‑facial, non‑intertriginous areas to minimize steroid‑related skin changes; step down to lower‑potency agents for maintenance alongside moisturizers and trigger management.