Tretinoin microsphere 0.025% is a topical retinoid formulated in a controlled‑release microsphere gel to treat acne and photoaged texture by normalizing keratinization, unclogging pores, and promoting collagen remodeling while reducing peak irritation versus conventional gels. Apply a pea‑sized amount to clean, fully dry skin at night, starting 2–3 nights weekly and increasing as tolerated; pair with gentle cleanser, non‑comedogenic moisturizer, and daily broad‑spectrum sunscreen. Expect purging and dryness in early weeks, with clearer texture over 8–12 weeks and continued gains thereafter. Avoid use on eczematous, sunburned, or broken skin and pause during strong procedures or waxing.